Simple cuboidal epithelial cells line the ducts of certain human exocrine glands. Various materials are transported into or out of the cells by diffusion. (The formula for surface area of a cube is \(6 \times S^2\), and the formula for the volume of a cube is \(S^3\), where \(S=\) the length of a side of the cube.)

Which of the following cube-shaped cells would be more efficient in removing waste by diffusion?

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Calculate the surface area to volume ratio:

$$ \frac{SA}{V} = \frac{6S^2}{S^3}$$ $$ = \frac{6}{S} $$

The surface area to volume ratio decreases as the side \(S\) increases.